I was getting this annoying Windows popup almost every minute while using Chrome:
"This app can’t run on your PC. To find a version for your PC, check with the software publisher.”
I initially suspected Chrome, and even tried uninstalling and reinstalling it, but the issue continued.
Finally, I disabled the McAfee WebAdvisor extension in Chrome, and the popup stopped immediately.
To confirm, I enabled the extension again, and the popup appeared almost instantly. Disabled it again, and it stopped.
So, in my case, McAfee WebAdvisor was the culprit.
Posting this in case someone else runs into the same issue and wastes time troubleshooting Chrome or Windows like I did.
TL;DR: If you keep getting the “This app can’t run on your PC” popup while using Chrome, try disabling McAfee WebAdvisor and see if it stops.